This can lead to hypertensive crises and a variety of neurological toxic effects and malignant hyperpyrexia, which can be fatal. MAOIs slow metabolism of amphetamines and increase their effects. Monoamine oxidase inhibitors (MAOIs) or other antidepressants: Do not take Adderall if you've taken MAOIs within 14 days.Pregnancy: There are no adequate and well-controlled studies in pregnant women and there may be a risk of long-term behavioral, including learning and memory deficits, or neurochemical changes for children born to mothers who took amphetamines while pregnant.

Liver or kidney problems: These organs may be affected by long-term use of Adderall.

Tics: The medication may exacerbate motor and phonic tics and Tourette’s syndrome. You don't need to worry that Adderall is causing tics, as some medications can, but it can cause tics that you otherwise have to become more noticeable.

Bipolar disorder: Stimulants may induce mixed/manic episode in patients with bipolar disorder.

Pre-existing psychosis: Stimulants may worsen symptoms of behavioral disturbance and thought disorder in patients with psychotic disorders.

Seizures: Stimulants may lower the convulsive threshold and increase seizures in patients with prior history of seizure or those with prior EEG (brain wave test) abnormalities.

In general, those with structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease or other serious heart problems should not take stimulants.

Hypertension and other cardiovascular conditions: Stimulants cause an increase in average blood pressure and heart rate that can carry risks for those with any underlying conditions, such as mild hypertension, heart failure, recent myocardial infarction, or ventricular arrhythmia.

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