There have also been reports that, in some cases, specific breeds of goats may be more susceptible than others and that goats may be more susceptible, or develop more severe pathology, than sheep. There were extensive descriptions of the clinical signs typical of PPRV infection in the period when the disease was first recognised (reviewed in ), as well as descriptions of the identification of the disease in various regions or in specific wildlife species. ĭespite the economic and social importance of PPR as a disease, and a number of recent publications discussing potential new vaccines, the disease itself has not received very close attention. The virus has been spreading continuously in recent decades, and is beginning to receive significant attention in an effort to control and possibly even eradicate the disease. It is widely distributed in Africa, the Middle East and Asia, and has a major economic impact on livestock keepers in developing countries, causing a severe disease in small ruminants (sheep and goats), livestock animals that are often the prerogative of the poorer groups in these countries, especially women.

Peste de petits ruminants virus (PPRV) is a paramyxovirus that belongs to the genus Morbillivirus. Measurement of the expression of various cytokines showed elements of a classic inflammatory response but also a relatively early induction of interleukin 10, which may be contributing to the observed disease. A consistent reduction in CD4 + T cells was observed at 4 days post infection (dpi). No lineage-specific difference in the pathogenicity of the virus isolates was observed, although there was evidence that even small numbers of cell culture passages could affect the degree of pathogenicity of an isolate. We have studied the early stages of pathogenesis in goats infected with six different isolates of Peste des petits ruminants virus representing all four known lineages of the virus.

Although, the spread of the disease and its economic impact has made it a focus of international concern, relatively little is known about the nature of the disease itself.

Peste des petits ruminants is a viral disease of sheep and goats that has spread through most of Africa as well as the Middle East and the Indian subcontinent.

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